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Common side effects of OxyContin may include: • Headache, drowsiness, tiredness, dizziness; or • Nausea, vomiting, constipation, stomach pain It is not a complete list of side effects, and others may occur. Take your doctor’s medical advice regarding side effects. Report side effects to FDA at 1-800-FDA-1088. How does OxyContin work? This medicine’s primary work efficiently manages moderate to severe acute or chronic pain when other treatments are insufficient. It works in the brain to switch how your body feels and responds to pain. 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